Loss or inhibition of lysosomal acid lipase in vitro leads to cholesteryl ester accumulation without affecting muscle formation or mitochondrial function

Loss or inhibition of lysosomal acid lipase in vitro leads to cholesteryl ester accumulation without affecting muscle formation or mitochondrial function

Skeletal muscle (SM) is essential for movement, stability, and overall body function, and it readily adapts to changes in energy demand. Myogenesis is energy-intensive and involves complex molecular and cellular events. We recently demonstrated that the absence of lysosomal acid lipase (LAL) in vivo...

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Bibliographic Details
Main Authors: Alena Akhmetshina, Laszlo Schooltink, Melina Amor, Katharina B. Kuentzel, Silvia Rainer, Ananya Nandy, Hansjoerg Habisch, Tobias Madl, Elizabeth Rendina-Ruedy, Katharina Leithner, Nemanja Vujić, Dagmar Kratky
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:BBA Advances
Subjects:
LAL
LAL deficiency
Energy metabolism
Primary myoblast
Skeletal muscle
Myogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2667160324000231
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