Two chromatographic methods for analyzing paracetamol in spiked human plasma with its toxic metabolite, N-acetyl parabenzoquinone imine and its antidote, N-acetyl-l-cysteine

Two chromatographic methods for analyzing paracetamol in spiked human plasma with its toxic metabolite, N-acetyl parabenzoquinone imine and its antidote, N-acetyl-l-cysteine

Abstract Acetaminophen, also known as paracetamol (APAP), is a highly utilized pharmaceutical agent on a global scale, particularly in the field of pediatrics. Regrettably, an overdose of APAP, resulting from the predominant oxidation, has the potential to trigger acute liver injury. The study’s goa...

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Bibliographic Details
Main Authors: Omar M El-Abassy, Michael Gamal Fawzy, Ebraam B. Kamel
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Detoxification
N-acetyl para benzoquinone imine
Paracetamol
Acetylcysteine
Chromatography
Plasma analysis
Online Access:https://doi.org/10.1038/s41598-025-86070-3
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https://doi.org/10.1038/s41598-025-86070-3

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