Anticancer efficacy of Spiruchostatin A: current insights into histone deacetylase inhibition and oncologic applications

Anticancer efficacy of Spiruchostatin A: current insights into histone deacetylase inhibition and oncologic applications

Abstract Spiruchostatin A also referred to as YM753 and OBP801, a cyclic peptide-based natural product derived from Pseudomonas sp., is distinguished by its potent inhibition of Class I histone deacetylases (HDACs). The modulation of epigenetic mechanisms by HDAC inhibitors is fundamental for alteri...

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Bibliographic Details
Main Authors: Saooda Ibrahim, Muhammad Umer Khan, Iqra Khurram, Muhammad Usman Ghani, Javad Sharifi-Rad, Daniela Calina
Format: Article
Language:English
Published: BMC 2025-03-01
Series:European Journal of Medical Research
Subjects:
Anticancer
Epigenetics
HDAC inhibitor
Histone deacetylase
Spiruchostatin A
Therapeutic potential
Online Access:https://doi.org/10.1186/s40001-025-02401-0
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https://doi.org/10.1186/s40001-025-02401-0

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