Broad-Spectrum Gramicidin S Derivatives with Potent Activity Against Multidrug-Resistant Gram-Negative ESKAPE Pathogens

Broad-Spectrum Gramicidin S Derivatives with Potent Activity Against Multidrug-Resistant Gram-Negative ESKAPE Pathogens

Background/Objectives: Multidrug-resistant Gram-negative ESKAPE pathogens, including <i>E. coli</i>, <i>K. pneumoniae</i>, <i>P. aeruginosa</i>, and <i>A. baumannii</i>, pose a significant global health threat. Gramicidin S, a potent cyclic antimicrobi...

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Bibliographic Details
Main Authors: John T. Kalyvas, Yifei Wang, Ornella Romeo, John R. Horsley, Andrew D. Abell
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Antibiotics
Subjects:
antibiotic resistance
antimicrobial peptides
antibiotics
gramicidin S
broad-spectrum
ESKAPE pathogens
Online Access:https://www.mdpi.com/2079-6382/14/5/423
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