STING-ΔN, a novel splice isoform of STING, modulates innate immunity and autophagy in response to DNA virus infection

STING-ΔN, a novel splice isoform of STING, modulates innate immunity and autophagy in response to DNA virus infection

Abstract Background Stimulator of interferon (IFN) genes (STING) is a central adaptor protein in the cGAS-STING signaling pathway, orchestrating the production of type I interferons (IFNs) in response to cytosolic DNA detection, a crucial mechanism in antiviral defense. However, further investigatio...

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Bibliographic Details
Main Authors: Jian Deng, Sheng-Nan Zheng, Jing Zhang, Cheng-Hao Li, Tao Li, Pei-Hui Wang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cell Communication and Signaling
Subjects:
cGAS
STING
STING-∆N
Alternative splicing
HPV
Antiviral immunity
Online Access:https://doi.org/10.1186/s12964-025-02305-w
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https://doi.org/10.1186/s12964-025-02305-w

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