BKCa channel as a novel regulator of cellular DNA damage response in human bronchial epithelial cells in the presence of particulate matter

BKCa channel as a novel regulator of cellular DNA damage response in human bronchial epithelial cells in the presence of particulate matter

Abstract While particulate matter (PM) is a well-studied genotoxic environmental agent, our understanding of the molecular mechanisms through which PM triggers its harmful health consequences remains insufficient. The respiratory epithelium serves as the primary site for the deposition of PM, thereb...

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Main Authors: Kamila Maliszewska-Olejniczak, Agata Kustra, Wojciech Szymański, Adrianna Dąbrowska-Hulka, Monika Żochowska, Bogusz Kulawiak, Piotr Bednarczyk
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
BKCa channel
DNA damage response
DNA-DSBs
DNA-SSBs
Apoptosis
PARP
Online Access:https://doi.org/10.1038/s41598-025-03824-9
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https://doi.org/10.1038/s41598-025-03824-9

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