Structural mechanisms behind the neutralisation of long-chain α-neurotoxins by broadly neutralising VHHs discovered using a consensus antigen

Structural mechanisms behind the neutralisation of long-chain α-neurotoxins by broadly neutralising VHHs discovered using a consensus antigen

Abstract Snakebite envenoming, a neglected tropical disease, affects millions globally, causing significant morbidity and mortality. Developing broadly neutralising monoclonal antibodies offers a promising approach to address the antigenic variation present in snake venoms. In this study, we designe...

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Main Authors: Anna Damsbo, Nick J. Burlet, Monica L. Fernández-Quintero, Melisa Benard-Valle, Max D. Overath, Alid Guadarrama-Martínez, Anneline Vlamynck, Ida Bisbo, Cesar Villalobos, Tulika Tulika, Alejandro Alagón, Johannes R. Loeffler, Andrew B. Ward, Kim Boddum, Jens Preben Morth, Esperanza Rivera-de-Torre, Andreas H. Laustsen
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-025-01600-4
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https://doi.org/10.1038/s42004-025-01600-4

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