The linker histone chaperone Prothymosin α (PTMA) is essential for efficient DNA damage repair and the recruitment of PARP1

The linker histone chaperone Prothymosin α (PTMA) is essential for efficient DNA damage repair and the recruitment of PARP1

Abstract Background Mammalian cells have numerous DNA repair pathways to repair lesions generated by replication errors, metabolism, and exogenous agents. Cells can sense and respond to DNA damage within seconds, suggesting that there is a highly effective sensor of lesions although the mechanistic...

Full description

Saved in:
Bibliographic Details
Main Authors: Ciara A. McKnight, Mary E. Graichen, Eric M. George, David T. Brown
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Epigenetics & Chromatin
Subjects:
Prothymosin α
Histone H1
Histone chaperone
Chromatin
Poly-ADP ribose polymerase 1
DNA damage repair
Online Access:https://doi.org/10.1186/s13072-025-00599-1
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s13072-025-00599-1

Similar Items