Senescent cell reduction does not improve recovery in mice under experimental autoimmune encephalomyelitis (EAE) induced demyelination

Senescent cell reduction does not improve recovery in mice under experimental autoimmune encephalomyelitis (EAE) induced demyelination

Abstract Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by immune cell-driven demyelination and progressive neurodegeneration. Senescent cells (SCs) have recently been observed in chronic MS lesions indicating their possible involvement in...

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Bibliographic Details
Main Authors: Zeeba Manavi, George S. Melchor, Meghan R. Bullard, Phillip S. Gross, Shinjini Ray, Pankaj Gaur, Maryna Baydyuk, Jeffrey K. Huang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Neuroinflammation
Subjects:
Immune-mediated demyelination
Experimental autoimmune encephalomyelitis
Cellular senescence
Myeloid cells
Senolytics
Multiple sclerosis
Online Access:https://doi.org/10.1186/s12974-025-03425-3
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https://doi.org/10.1186/s12974-025-03425-3

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