GABA, Glx, and GSH in the cerebellum: their role in motor performance and learning across age groups

GABA, Glx, and GSH in the cerebellum: their role in motor performance and learning across age groups

IntroductionThe cerebellum is essential for motor control and learning, relying on structural and functional integrity. Age-related atrophy leads to Purkinje cell loss, but subtle neurochemical changes in GABA, Glx (glutamate + glutamine), and glutathione (GSH) may precede degeneration and contribut...

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Bibliographic Details
Main Authors: Shanti Van Malderen, Melina Hehl, Stefanie Verstraelen, Robbe Breugelmans, Georg Oeltzschner, Stephan P. Swinnen, Koen Cuypers
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
magnetic resonance spectroscopy
cerebellum
aging
gamma-aminobutyric acid
Glx
glutathione
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1626417/full
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https://www.frontiersin.org/articles/10.3389/fnagi.2025.1626417/full

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