CRISPR-Cas Dynamics in Carbapenem-Resistant and Carbapenem-Susceptible <i>Klebsiella pneumoniae</i> Clinical Isolates from a Croatian Tertiary Hospital

CRISPR-Cas Dynamics in Carbapenem-Resistant and Carbapenem-Susceptible <i>Klebsiella pneumoniae</i> Clinical Isolates from a Croatian Tertiary Hospital

(1) Background: CRISPR-Cas systems provide adaptive immunity against mobile genetic elements (MGEs) carrying antimicrobial resistance (AMR) genes. Carbapenem-resistant (CR) <i>Klebsiella pneumoniae</i> is a major public health concern, and the role of CRISPR-Cas in its resistance is unde...

Full description

Saved in:

Bibliographic Details
Main Authors:	Ivana Jurić, Marko Jelić, Manda Markanović, Lucija Kanižaj, Zrinka Bošnjak, Ana Budimir, Tomislav Kuliš, Arjana Tambić-Andrašević, Ivana Ivančić-Baće, Ivana Mareković
Format:	Article
Language:	English
Published:	MDPI AG 2025-06-01
Series:	Pathogens
Subjects:	<i>Klebsiella pneumoniae</i> CRISPR-Cas system CRISPR loci subtypes I-E and I-E* carbapenemase genes carbapenem resistance
Online Access:	https://www.mdpi.com/2076-0817/14/6/604
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

CRISPR/Cas: An Emerging Toolbox for Engineering Virus Resistance in Plants
by: Xiaohui Zhan, et al.
Published: (2024-11-01)

ESBL-Producing <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> Exhibit Divergent Paths During In-Human Evolution Towards Carbapenem Resistance
by: Michelle Chioma Kalu, et al.
Published: (2025-06-01)

Development of a Recombinase Polymerase Amplification-Coupled CRISPR/Cas12a Platform for Rapid Detection of Antimicrobial-Resistant Genes in Carbapenem-Resistant <i>Enterobacterales</i>
by: Ji Woo Yang, et al.
Published: (2024-11-01)

Comparative Genomics of <i>Bifidobacterium animalis</i> subsp. <i>lactis</i> Reveals Strain-Level Hyperdiversity, Carbohydrate Metabolism Adaptations, and CRISPR-Mediated Phage Immunity
by: Ozge Can, et al.
Published: (2025-03-01)

Kharon Is Crucial for <i>Trypanosoma cruzi</i> Morphology but Does Not Impair In Vitro Infection
by: Jose Luis Saenz-Garcia, et al.
Published: (2025-03-01)

Emergence of Multidrug-Resistant <i>Campylobacter jejuni</i> in a Common Variable Immunodeficiency Patient: Evolution of Resistance Under the Selective Antibiotic Pressure
by: Tajana Juzbašić, et al.
Published: (2025-06-01)

CRISPR/Cas9-Mediated Knockout of the <i>Corazonin</i> Gene Indicates Its Regulation on the Cuticle Development of Desert Locusts (<i>Schistocerca gregaria</i>)
by: Yingying He, et al.
Published: (2025-07-01)

Determination of Technological Properties and CRISPR Profiles of <i>Streptococcus thermophilus</i> Isolates Obtained from Local Yogurt Samples
by: Hatice Sevgi Coban, et al.
Published: (2024-11-01)

Breaking Through Resistance: Carbapenem-Resistant Nocardia?!—A Case Report
by: Vlad-Sabin Ivan, et al.
Published: (2024-11-01)

The CRISPR/Cas9-Mediated Knockout of <i>VgrG2</i> in Wild Pathogenic <i>E. coli</i> to Alleviate the Effects on Cell Damage and Autophagy
by: Tian-Ling Pan, et al.
Published: (2025-03-01)

Knocked-Out <i>Bombyx mori</i> Protein Disulfide Isomerase Decreases Silk Yields and Mechanical Properties by Affecting the Post-Translational Modification of Silk Proteins
by: Shifeng Yang, et al.
Published: (2025-06-01)

Improving the Genome Editing Efficiency of CRISPR/Cas9 in Melon and Watermelon
by: Zhuanrong Wang, et al.
Published: (2024-10-01)

Generation of TP53 knock out induced pluripotent stem cell using CRISPR/Cas9
by: Haonan Zhou, et al.
Published: (2025-06-01)

Exploring Virulence Characteristics of Clinical <i>Escherichia coli</i> Isolates from Greece
by: Lazaros A. Gagaletsios, et al.
Published: (2025-06-01)

Antibiotic-Resistant <i>Pseudomonas aeruginosa</i>: Current Challenges and Emerging Alternative Therapies
by: Minqi Hu, et al.
Published: (2025-04-01)

Disruption of <i>FW2.2</i>-like Genes Enhances Metallic Micronutrient Accumulation in Brown Rice
by: Qingsong Gao, et al.
Published: (2025-07-01)

Construction of an Editing System for Forest Tree Genomes Based on an Efficient Visual Screening Marker in <i>Eucalyptus urophylla</i> × <i>Eucalyptus grandis</i>
by: Min Su, et al.
Published: (2025-04-01)

ABA Enhances Drought Resistance During Rapeseed (<i>Brassica napus</i> L.) Seed Germination Through the Gene Regulatory Network Mediated by ABA Insensitive 5
by: Dan Luo, et al.
Published: (2025-04-01)

Innovative Antibiotic Therapies for Carbapenem-Resistant Gram-Negative Bacterial Infections: Clinical Efficacy, Safety, and Comparative Studies
by: Majid Eslami, et al.
Published: (2025-01-01)

Risk Factors for Non-Carbapenemase-Producing Carbapenem-Resistant <i>Enterobacterales</i> Infections: A Retrospective Cohort Study
by: Sayaka Mabuchi, et al.
Published: (2025-05-01)

The Effect of <i>G0S2</i> Gene Knockout on the Proliferation, Apoptosis, and Differentiation of Chicken Preadipocytes
by: Yantao Li, et al.
Published: (2025-03-01)

Molecular Insights into Rice Immunity: Unveiling Mechanisms and Innovative Approaches to Combat Major Pathogens
by: Muhammad Usama Younas, et al.
Published: (2025-06-01)

Molecular Mechanisms Underlying Defense Responses of Potato (<i>Solanum tuberosum</i> L.) to Environmental Stress and CRISPR/Cas-Mediated Engineering of Stress Tolerance
by: Maxim Sutula, et al.
Published: (2025-06-01)

Involvement of the Methyltransferase CcLaeA in Regulating Laccase Production in <i>Curvularia clavata</i> J1
by: Changyu Pi, et al.
Published: (2025-03-01)

Cefiderocol in Combating Carbapenem-Resistant <i>Acinetobacter baumannii</i>: Action and Resistance
by: Bahman Yousefi, et al.
Published: (2024-11-01)

Haploid Production in <i>Cannabis sativa</i>: Recent Updates, Prospects, and Perspectives
by: S.M. Ahsan, et al.
Published: (2025-06-01)

Targeted Gene Knock-Out of <i>Fel d1</i> in Fetal Fibroblasts Using CRISPR–Cas9: Implications for Cat Allergies
by: Ling Li, et al.
Published: (2025-03-01)

AAV2 delivery of the saCas9 gene results in presentation of an HLA-A∗02:01-restricted T cell epitope potent to induce T cell cytotoxicity
by: Susana S. Najera, et al.
Published: (2025-09-01)

Generation of a homozygous ABCA7 knockout cell line (AHMUCNi002-A) in human iPSCs using CRISPR/Cas9
by: Juanjuan Li, et al.
Published: (2025-06-01)

Breeding for Sclerotinia Blight Resistance on Peanut in the U.S.: A Review
by: Kelly D. Chamberlin, et al.
Published: (2025-02-01)

Cystic echinococcosis
by: S. B. Chuelov, et al.
Published: (2023-04-01)

Integrating Agronomic and Molecular Advancements to Enhance Nitrogen Use Efficiency (NUE) and Promote Sustainable Rice Production
by: Uttam Bahadur Kunwar, et al.
Published: (2025-05-01)

Engineering High-Amylose and High-Dietary-Fibre Barley Grains Through Multiplex Genome Editing of Four Starch-Synthetic Genes
by: Qiang Yang, et al.
Published: (2025-06-01)

CRISPR/Cas9-Mediated <i>BocPDSs</i> Gene Editing in Chinese Kale Using the Endogenous tRNA-Processing System
by: Yudan Wang, et al.
Published: (2024-11-01)

Isolation, Identification, and Antibiotic Resistance, CRISPR System Analysis of <i>Escherichia coli</i> from Forest Musk Deer in Western China
by: Kaiwei Yang, et al.
Published: (2025-07-01)

An RPA-Based CRISPR/Cas12a Assay in Combination with a Lateral Flow Assay for the Rapid Detection of <i>Shigella flexneri</i> in Food Samples
by: Jieru Xu, et al.
Published: (2024-10-01)

<i>HOM2</i> Deletion by CRISPR-Cas9 in <i>Saccharomyces cerevisiae</i> for Decreasing Higher Alcohols in Whiskey
by: Jiaojiao He, et al.
Published: (2024-11-01)

<i>AtAUEs</i>, a Small Family of ABA Up-Regulated EAR Motif-Containing Proteins Regulate ABA Responses in Arabidopsis
by: Wei Wang, et al.
Published: (2024-11-01)

CRISPR-Based Editing of the <i>Medicago truncatula LEC1</i> Gene
by: Elina A. Potsenkovskaia, et al.
Published: (2024-11-01)

Antibacterial Therapy Options for Infections Caused by Carbapenem-Resistant <i>Acinetobacter baumannii</i>
by: A. R. Goncharova, et al.
Published: (2024-11-01)