Brown adipose tissue-derived extracellular vesicles regulate hepatocyte mitochondrial activity to alleviate high-fat diet-induced jawbone osteoporosis in mice

Brown adipose tissue-derived extracellular vesicles regulate hepatocyte mitochondrial activity to alleviate high-fat diet-induced jawbone osteoporosis in mice

BackgroundLipid metabolic disorder (LMD) serves as a systemic driver of osteoporosis (OP), with jawbone osteoporosis (JOP) representing a clinically significant yet underexplored complication. Current clinical treatments for JOP remain suboptimal, highlighting the need for innovative approaches. The...

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Main Authors: Kai Zhang, Sha Zhang, Guorong Deng, Guangxiang He, Yuan Yuan, Yu Fu, Yihan Liu, Zhen Gong, Liang Kong, Chenxi Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Endocrinology
Subjects:
lipid metabolic disorder
jawbone osteoporosis
brown adipose tissue
extracellular vesicles
mitochondrial activity
osteogenic microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1583408/full
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https://www.frontiersin.org/articles/10.3389/fendo.2025.1583408/full

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