Notch1 signaling regulates Sox9 and VEGFA expression and governs BMP2-induced endochondral ossification of mesenchymal stem cells

Notch1 signaling regulates Sox9 and VEGFA expression and governs BMP2-induced endochondral ossification of mesenchymal stem cells

Although bone morphogenetic protein 2 (BMP2) can induce chondrogenic differentiation of mesenchymal stem cells (MSCs), its induction of endochondral ossification limits the application of BMP2-based cartilage regeneration. Here, we clarified the mechanisms of BMP2-induced endochondral ossification o...

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Bibliographic Details
Main Authors: Jing Zou, Chengcheng Du, Senrui Liu, Piao Zhao, Shengqiang Gao, Bowen Chen, Xiangdong Wu, Wei Huang, Zhenglin Zhu, Junyi Liao
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-05-01
Series:Genes and Diseases
Subjects:
BMP2
Chondrogenic differentiation
Endochondral ossification
Mesenchymal stem cells
Notch1 signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304224001338
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http://www.sciencedirect.com/science/article/pii/S2352304224001338

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