Tubular cell loss in early inv/nphp2 mutant kidneys represents a possible homeostatic mechanism in cortical tubular formation.

Tubular cell loss in early inv/nphp2 mutant kidneys represents a possible homeostatic mechanism in cortical tubular formation.

Inversion of embryonic turning (inv) cystic mice develop multiple renal cysts and are a model for type II nephronophthisis (NPHP2). The defect of planar cell polarity (PCP) by oriented cell division was proposed as the underlying cellular phenotype, while abnormal cell proliferation and apoptosis oc...

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Bibliographic Details
Main Authors: Masaki Shigeta, Hirotaka Kanazawa, Takahiko Yokoyama
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0198580/1/pone.0198580.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210219%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210219T123651Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=ce5ef2e4f2c84e8e536b8a8ec7e5e3b3cf96f89b8d87196182e8348bcdc501f3965b79a0ea1fcd968f0980c5cd1878c902e1aaab410a5405d0d4b88b648ff7d9c8c60fe66d4c61ec743528ee944299e7bf85f60764253e5d5b368220e60beeb432bbc71ea5fb8dd022d64a0e66ecc1ce9dad8652f0e4291477a7e1b5de81aecfb3eb50c0dd91da7f43b5952fdfe7a771dc86a33b4c5ba42fa3d0dd2777547ab3d9bfa7618c2e95315f6bd5c287e487dffc65504fe5860fe43d0e433ae12831bb3bcbee8bc97be6e7f5a68964dfcbb0fc58ac22284b1fe0b0dfb010e7ae8cf82c39bf2c7d776e083bae1ff907a2cf3ebb02ad97ba9222c116420106ad55684b73
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