S-Adenosylmethionine Inhibits Plasminogen-Activating Inhibitor-1 and Protects Male Mice from FOLFOX-Induced Liver InjurySummary

Background & Aims: FOLFOX, often used in patients with colorectal liver metastases, can cause sinusoidal obstruction syndrome (SOS) hindering subsequent treatment. S-adenosylmethionine (SAMe) is hepatoprotective and here we investigated whether it protects against FOLFOX-induced hepatotoxici...

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Bibliographic Details
Main Authors: Alexandra Gangi, Tony W.H. Li, Youngyi Lim, Swati Chandla, Andrea Floris, Arash Khangholi, Maria Lauda Tomasi, Shelly C. Lu
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
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Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X25000542
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