Trabectedin and Lurbinectedin Modulate the Interplay between Cells in the Tumour Microenvironment—Progresses in Their Use in Combined Cancer Therapy

Trabectedin and Lurbinectedin Modulate the Interplay between Cells in the Tumour Microenvironment—Progresses in Their Use in Combined Cancer Therapy

Trabectedin (TRB) and Lurbinectedin (LUR) are alkaloid compounds originally isolated from <i>Ecteinascidia turbinata</i> with proven antitumoral activity. Both molecules are structural analogues that differ on the tetrahydroisoquinoline moiety of the C subunit in TRB, which is replaced b...

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Bibliographic Details
Main Authors: Adrián Povo-Retana, Rodrigo Landauro-Vera, Carlota Alvarez-Lucena, Marta Cascante, Lisardo Boscá
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Molecules
Subjects:
trabectedin
lurbinectedin
macrophages
lymphocytes
ecteinascidins
combined therapies
Online Access:https://www.mdpi.com/1420-3049/29/2/331
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