Transgenic expression of a T cell epitope in Strongyloides ratti reveals that helminth-specific CD4+ T cells constitute both Th2 and Treg populations.

Transgenic expression of a T cell epitope in Strongyloides ratti reveals that helminth-specific CD4+ T cells constitute both Th2 and Treg populations.

Helminths are distinct from microbial pathogens in both size and complexity, and are the likely evolutionary driving force for type 2 immunity. CD4+ helper T cells can both coordinate worm clearance and prevent immunopathology, but issues of T cell antigen specificity in the context of helminth-indu...

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Bibliographic Details
Main Authors: Bonnie Douglas, Yun Wei, Xinshe Li, Annabel Ferguson, Li-Yin Hung, Christopher Pastore, Jonathan R Kurtz, James B McLachlan, Thomas J Nolan, James Lok, De'Broski R Herbert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-07-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009709&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009709&type=printable

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