Neutrophil expansion defines an immunoinhibitory peripheral and intratumoral inflammatory milieu in resected non-small cell lung cancer: a descriptive analysis of a prospectively immunoprofiled cohort

Neutrophil expansion defines an immunoinhibitory peripheral and intratumoral inflammatory milieu in resected non-small cell lung cancer: a descriptive analysis of a prospectively immunoprofiled cohort

Background The biological underpinnings of the prognostic and predictive significance of a relative neutrophilia in patients with non-small lung cancer (NSCLC) are undefined. We sought to comprehensively examine the relationships between circulating and intratumoral neutrophil populations and featur...

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Main Authors: Jing Wang, Ignacio I Wistuba, Alexandre Reuben, Chantale Bernatchez, Tina Cascone, Jianjun Zhang, Boris Sepesi, Edwin R Parra, Ara A Vaporciyan, Kyle G Mitchell, Lixia Diao, Tatiana Karpinets, Marcelo V Negrao, Hai T Tran, Erin M Corsini, Lorenzo Federico, Hitoshi Dejima, Alejandro Francisco-Cruz, Mara B Antonoff, Stephen G Swisher, John V Heymach, Don L Gibbons, Cara L Haymaker
Format: Article
Language:English
Published: BMJ Publishing Group 2020-05-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/8/1/e000405.full
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https://jitc.bmj.com/content/8/1/e000405.full

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