TPL-2 restricts Ccl24-dependent immunity to Heligmosomoides polygyrus.

TPL-2 restricts Ccl24-dependent immunity to Heligmosomoides polygyrus.

TPL-2 (COT, MAP3K8) kinase activates the MEK1/2-ERK1/2 MAPK signaling pathway in innate immune responses following TLR, TNFR1 and IL-1R stimulation. TPL-2 contributes to type-1/Th17-mediated autoimmunity and control of intracellular pathogens. We recently demonstrated TPL-2 reduces severe airway all...

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Main Authors: Yashaswini Kannan, Lewis J Entwistle, Victoria S Pelly, Jimena Perez-Lloret, Alan W Walker, Steven C Ley, Mark S Wilson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-07-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006536&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006536&type=printable

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