Assessing the selective impact of histone modifying drugs on adenoid cystic carcinoma cells and their stem cell counterparts

Assessing the selective impact of histone modifying drugs on adenoid cystic carcinoma cells and their stem cell counterparts

Abstract Background Adenoid cystic carcinoma (ACC) is a rare, malignant neoplasm of the salivary glands that, despite its slow growth, exhibits aggressive behavior, including perineural invasion, high recurrence rates, and distant metastasis. The lack of effective systemic therapies, combined with t...

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Bibliographic Details
Main Authors: Carolina Emerick, Luan César Silva, Yeejin Jang, Pablo A. Vargas, Cristiane H. Squarize, Rogerio M. Castilho
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Cancer
Subjects:
Epigenetic
Salivary gland cancer
Adenoid cystic carcinoma
Drug screening
Cancer stem cell
Online Access:https://doi.org/10.1186/s12885-025-14739-z
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https://doi.org/10.1186/s12885-025-14739-z

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