5‐azacytidine inhibits nonsense‐mediated decay in a MYC‐dependent fashion

5‐azacytidine inhibits nonsense‐mediated decay in a MYC‐dependent fashion

Abstract Nonsense‐mediated RNA decay (NMD) is an RNA‐based quality control mechanism that eliminates transcripts bearing premature translation termination codons (PTC). Approximately, one‐third of all inherited disorders and some forms of cancer are caused by nonsense or frame shift mutations that i...

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Main Authors: Madhuri Bhuvanagiri, Joe Lewis, Kerstin Putzker, Jonas P Becker, Stefan Leicht, Jeroen Krijgsveld, Richa Batra, Brad Turnwald, Bogdan Jovanovic, Christian Hauer, Jana Sieber, Matthias W Hentze, Andreas E Kulozik
Format: Article
Language:English
Published: Springer Nature 2014-10-01
Series:EMBO Molecular Medicine
Subjects:
5‐azacytidine
MYC
nonsense‐mediated decay
premature termination codons
Online Access:https://doi.org/10.15252/emmm.201404461
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https://doi.org/10.15252/emmm.201404461

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