Mesenchymal Stem Cells and Inflammatory Cardiomyopathy: Cardiac Homing and Beyond
Under conventional heart failure therapy, inflammatory cardiomyopathy usually has a progressive course, merging for alternative interventional strategies. There is accumulating support for the application of cellular transplantation as a strategy to improve myocardial function. Mesenchymal stem cell...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.4061/2011/757154 |
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| _version_ | 1832565137173643264 |
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| author | S. Van Linthout Ch. Stamm H.-P. Schultheiss C. Tschöpe |
| author_facet | S. Van Linthout Ch. Stamm H.-P. Schultheiss C. Tschöpe |
| author_sort | S. Van Linthout |
| collection | DOAJ |
| description | Under conventional heart failure therapy, inflammatory cardiomyopathy usually has a progressive course, merging for alternative interventional strategies. There is accumulating support for the application of cellular transplantation as a strategy to improve myocardial function. Mesenchymal stem cells (MSCs) have the advantage over other stem cells that they possess immunomodulatory features, making them attractive candidates for the treatment of inflammatory cardiomyopathy. Studies in experimental models of inflammatory cardiomyopathy have consistently demonstrated the potential of MSCs to reduce cardiac injury and to improve cardiac function. This paper gives an overview about how inflammation triggers the functionality of MSCs and how it induces cardiac homing. Finally, the potential of intravenous application of MSCs by inflammatory cardiomyopathy is discussed. |
| format | Article |
| id | doaj-art-f5ff8fe4aafc44c3a0f93065ba36d726 |
| institution | Kabale University |
| issn | 2090-0597 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-f5ff8fe4aafc44c3a0f93065ba36d7262025-02-03T01:09:27ZengWileyCardiology Research and Practice2090-05972011-01-01201110.4061/2011/757154757154Mesenchymal Stem Cells and Inflammatory Cardiomyopathy: Cardiac Homing and BeyondS. Van Linthout0Ch. Stamm1H.-P. Schultheiss2C. Tschöpe3Berlin-Brandenburg Center for Regenerative Therapies, Charité—University Medicine Berlin, Campus Virchow, 13353 Berlin, GermanyGermany Heart Institute Berlin, Charité—University Medicine Berlin, Campus Virchow, 13353 Berlin, GermanyDepartment of Cardiology and Pneumology, Charité—University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, GermanyBerlin-Brandenburg Center for Regenerative Therapies, Charité—University Medicine Berlin, Campus Virchow, 13353 Berlin, GermanyUnder conventional heart failure therapy, inflammatory cardiomyopathy usually has a progressive course, merging for alternative interventional strategies. There is accumulating support for the application of cellular transplantation as a strategy to improve myocardial function. Mesenchymal stem cells (MSCs) have the advantage over other stem cells that they possess immunomodulatory features, making them attractive candidates for the treatment of inflammatory cardiomyopathy. Studies in experimental models of inflammatory cardiomyopathy have consistently demonstrated the potential of MSCs to reduce cardiac injury and to improve cardiac function. This paper gives an overview about how inflammation triggers the functionality of MSCs and how it induces cardiac homing. Finally, the potential of intravenous application of MSCs by inflammatory cardiomyopathy is discussed.http://dx.doi.org/10.4061/2011/757154 |
| spellingShingle | S. Van Linthout Ch. Stamm H.-P. Schultheiss C. Tschöpe Mesenchymal Stem Cells and Inflammatory Cardiomyopathy: Cardiac Homing and Beyond Cardiology Research and Practice |
| title | Mesenchymal Stem Cells and Inflammatory Cardiomyopathy: Cardiac Homing and Beyond |
| title_full | Mesenchymal Stem Cells and Inflammatory Cardiomyopathy: Cardiac Homing and Beyond |
| title_fullStr | Mesenchymal Stem Cells and Inflammatory Cardiomyopathy: Cardiac Homing and Beyond |
| title_full_unstemmed | Mesenchymal Stem Cells and Inflammatory Cardiomyopathy: Cardiac Homing and Beyond |
| title_short | Mesenchymal Stem Cells and Inflammatory Cardiomyopathy: Cardiac Homing and Beyond |
| title_sort | mesenchymal stem cells and inflammatory cardiomyopathy cardiac homing and beyond |
| url | http://dx.doi.org/10.4061/2011/757154 |
| work_keys_str_mv | AT svanlinthout mesenchymalstemcellsandinflammatorycardiomyopathycardiachomingandbeyond AT chstamm mesenchymalstemcellsandinflammatorycardiomyopathycardiachomingandbeyond AT hpschultheiss mesenchymalstemcellsandinflammatorycardiomyopathycardiachomingandbeyond AT ctschope mesenchymalstemcellsandinflammatorycardiomyopathycardiachomingandbeyond |