Inhalable biomimetic polyunsaturated fatty acid-based nanoreactors for peroxynitrite-augmented ferroptosis potentiate radiotherapy in lung cancer

Inhalable biomimetic polyunsaturated fatty acid-based nanoreactors for peroxynitrite-augmented ferroptosis potentiate radiotherapy in lung cancer

Abstract The limited efficacy and poor tumor accumulation remain crucial challenges for radiotherapy against lung cancer. To address these limitations, we rationally developed a polyunsaturated fatty acid (PUFA)-based nanoreactor (DHA-N@M) camouflaged with macrophage cell membrane to improve tumoral...

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Bibliographic Details
Main Authors: Yiting Chen, Xueli Huang, Ruining Hu, Enhao Lu, Kuankuan Luo, Xin Yan, Zhiwen Zhang, Yan Ma, Minghe Zhang, Xianyi Sha
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Nanobiotechnology
Subjects:
Radiotherapy
Ferroptosis
Lung cancer
Inhalation
Nanoreactor
Online Access:https://doi.org/10.1186/s12951-025-03409-8
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https://doi.org/10.1186/s12951-025-03409-8

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