High-Calorie Diet Consumption Induces Lac-Phe Changes in the Brain in a Time-of-Day Manner Independent of Exercise

<b>Background/Objectives:</b> N-lactoyl-phenylalanine (Lac-Phe), an exercise-induced metabolite, has been shown to reduce food intake, decrease body weight and adiposity, and improve glucose homeostasis without affecting energy expenditure. Until now, Lac-Phe has mainly been investigated...

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Bibliographic Details
Main Authors: Jarne Jermei, Han Jiao, Ayano Shiba, Julia C. Goedhart, Roberta Tandari, Andries Kalsbeek, Eduard A. Struys, Chun-Xia Yi
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Metabolites
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Online Access:https://www.mdpi.com/2218-1989/15/6/375
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