Cytoplasmic connexin43-microtubule interactions promote glioblastoma stem-like cell maintenance and tumorigenicity

Cytoplasmic connexin43-microtubule interactions promote glioblastoma stem-like cell maintenance and tumorigenicity

Abstract Glioblastoma (GBM) is the most common primary tumor of the central nervous system. One major challenge in GBM treatment is the resistance to chemotherapy and radiotherapy observed in subpopulations of cancer cells, including GBM stem-like cells (GSCs). These cells have the capacity to self-...

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Main Authors: James W. Smyth, Sujuan Guo, Lata Chaunsali, Laurie O’Rourke, Jacob Dahlka, Stacie Deaver, Michael Lunski, Elmar Nurmemmedov, Harald Sontheimer, Zhi Sheng, Robert G. Gourdie, Samy Lamouille
Format: Article
Language:English
Published: Nature Publishing Group 2025-05-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07514-2
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https://doi.org/10.1038/s41419-025-07514-2

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