Spatial visualization provides insight into immune modulation by an L-DBF vaccine formulation against Shigella

Spatial visualization provides insight into immune modulation by an L-DBF vaccine formulation against Shigella

Shigellosis remains a global public health problem, especially in regions with poor sanitation measures. Our prior work has demonstrated the protective efficacy of a three-dose regimen of L-DBF, a recombinant fusion of IpaD and IpaB from Shigella flexneri with the LTA1 moiety of enterotoxigenic E. c...

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Bibliographic Details
Main Authors: Ti Lu, Skyler T. Kramer, Mary A. York, Mst Nusrat Zahan, Debaki R. Howlader, Zackary K. Dietz, Sean K. Whittier, Nathan J. Bivens, Alexander Jurkevich, Lyndon M. Coghill, William D. Picking, Wendy L. Picking
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
Shigella
intranasal vaccine
spatial transcriptomics
immune modulation
fibroblasts
cardiomyocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1577040/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1577040/full

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