Tissue-colonizing disseminated tumor cells secrete prostaglandin E2 to promote NK cell dysfunction and evade anti-metastatic immunity

Tissue-colonizing disseminated tumor cells secrete prostaglandin E2 to promote NK cell dysfunction and evade anti-metastatic immunity

Summary: Natural killer (NK) cells are critical for anti-metastatic immunity and can eliminate metastasizing tumor cells within circulation and sites of metastatic seeding. Here, we show that disseminated tumor cells (DTCs) colonizing the mouse lung secrete prostaglandin E2 (PGE2) to locally induce...

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Main Authors: Anna-Marie Pedde, Hyunu Kim, Sainitin Donakonda, Tobias Baumann, Felix Bayerl, Philippa Meiser, Anna Hirschberger, Christine Klement, Simon Grassmann, Rupert Öllinger, Norbert Hüser, Daniel Hartmann, Melanie Laschinger, Joseph A. Trapani, Alfred Zippelius, Tobias Bald, Gabriela M. Wiedemann, Roland Rad, Joseph C. Sun, Bastian Höchst, Jan P. Böttcher
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Cell Reports
Subjects:
CP: Immunology
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724012063
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http://www.sciencedirect.com/science/article/pii/S2211124724012063

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