An In Silico Investigation of the Pathogenic G151R G Protein-Gated Inwardly Rectifying K<sup>+</sup> Channel 4 Variant to Identify Small Molecule Modulators

An In Silico Investigation of the Pathogenic G151R G Protein-Gated Inwardly Rectifying K<sup>+</sup> Channel 4 Variant to Identify Small Molecule Modulators

Primary aldosteronism is characterised by the excessive production of aldosterone, which is a key regulator of salt metabolism, and is the most common cause of secondary hypertension. Studies have investigated the association between primary aldosteronism and genetic alterations, with pathogenic mut...

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Bibliographic Details
Main Authors: Eleni Pitsillou, Julia J. Liang, Noa Kino, Jessica L. Lockwood, Andrew Hung, Assam El-Osta, Asmaa S. AbuMaziad, Tom C. Karagiannis
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Biology
Subjects:
primary aldosteronism
G protein-gated ion channels
KCNJ5
GIRK4
G151R variant
Online Access:https://www.mdpi.com/2079-7737/13/12/992
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