2-Methoxyestradiol attenuates lung injury induced by chronic intermittent hypoxia via inhibiting the HIF1-α/SLC7A11 pathway

2-Methoxyestradiol attenuates lung injury induced by chronic intermittent hypoxia via inhibiting the HIF1-α/SLC7A11 pathway

Abstract Ferroptosis is a novel type of programmed cell death associated with lung injury induced by chronic intermittent hypoxia (CIH). 2-Methoxyestradiol (2-ME2), as an inhibitor of Hypoxia-inducible factor 1 alpha (HIF-1α), affects HIF-1α-related biological processes. This study aimed to explore...

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Bibliographic Details
Main Authors: Jia Chen, Hansheng Xie, Wenqian Chen, Ting Lin, Shiyuan Huang, Yaqi Liu, Jiefeng Huang, Ningfang Lian
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Obstructive sleep apnea
Chronic intermittent hypoxia
HIF-1α
SLC7A11
Ferroptosis
Lung injury
Online Access:https://doi.org/10.1038/s41598-025-02675-8
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https://doi.org/10.1038/s41598-025-02675-8

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