Mutations in Genes with a Role in Cell Envelope Biosynthesis Render Gram-Negative Bacteria Highly Susceptible to the Anti-Infective Small Molecule D66

Mutations in Genes with a Role in Cell Envelope Biosynthesis Render Gram-Negative Bacteria Highly Susceptible to the Anti-Infective Small Molecule D66

Anti-infectives include molecules that target microbes in the context of infection but lack antimicrobial activity under conventional growth conditions. We previously described D66, a small molecule that kills the Gram-negative pathogen <i>Salmonella enterica</i> serovar Typhimurium (<...

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Bibliographic Details
Main Authors: Samual C. Allgood, Calvin A. Ewing, Weiping Chu, Steffen Porwollik, Michael McClelland, Corrella S. Detweiler
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Microorganisms
Subjects:
AcrAB-TolC
anti-infective
efflux pump
<i>gmhB/yaeD</i>
inner membrane
lipopolysaccharide (LPS)
Online Access:https://www.mdpi.com/2076-2607/13/7/1521
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