Concentration‐Based Analysis of Metal‐Induced Tau Fibrillar versus non‐fibrillar Aggregation: Implications for Neurotoxicity in Alzheimer's Disease

Concentration‐Based Analysis of Metal‐Induced Tau Fibrillar versus non‐fibrillar Aggregation: Implications for Neurotoxicity in Alzheimer's Disease

Abstract Tau protein aggregation is the most significant factor in Alzheimer's disease (AD) pathogenesis, and the accumulation of metal ions in the brain is considered a key factor in the development of this disease. Tau protein exhibits two distinct aggregate structures: fibrillar and non‐fibr...

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Bibliographic Details
Main Authors: Mahzad Irandoust, Afrooz Anbaraki, Zahra Dindar, Atiyeh Ghasemi, Ali Akbar Saboury, Saeed Rayati, Arefeh Seyedarabi
Format: Article
Language:English
Published: Wiley-VCH 2025-08-01
Series:ChemistryOpen
Subjects:
Metal ions
Tau protein
Fibrillation
Aggregation
Cytotoxicity
Online Access:https://doi.org/10.1002/open.202400493
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https://doi.org/10.1002/open.202400493

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