A computational model reveals an early transient decrease in fiber cross-linking that unlocks adult regeneration

A computational model reveals an early transient decrease in fiber cross-linking that unlocks adult regeneration

Abstract The decline in regeneration efficiency after birth in mammals is a significant roadblock for regenerative medicine in tissue repair. We previously developed a computational agent based-model (ABM) that recapitulates mechanical interactions between cells and the extracellular-matrix (ECM), t...

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Main Authors: Anastasia Pacary, Diane Peurichard, Laurence Vaysse, Paul Monsarrat, Clémence Bolut, Adeline Girel, Christophe Guissard, Anne Lorsignol, Valérie Planat-Benard, Jenny Paupert, Marielle Ousset, Louis Casteilla
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:npj Regenerative Medicine
Online Access:https://doi.org/10.1038/s41536-024-00373-z
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https://doi.org/10.1038/s41536-024-00373-z

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