Comparison of carbonic anhydrase-IX-targeted trifunctional radioligands between linear- and branched-chain arrangements

Comparison of carbonic anhydrase-IX-targeted trifunctional radioligands between linear- and branched-chain arrangements

BackgroundCarbonic anhydrase-IX (CA-IX) is overexpressed in tumors due to hypoxic conditions and considered an attractive biomarker for tumor-targeting radioligands. The introduction of an albumin binder (ALB) to radioligands can delay their renal clearance, resulting in increased radioactivity deli...

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Bibliographic Details
Main Authors: Kazuma Nakashima, Takayoshi Ichinose, Hiroyuki Watanabe, Masahiro Ono
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Nuclear Medicine
Subjects:
CA-IX
imidazothiadiazole sulfonamide
DOTA
albumin binder
linear-chain arrangement
branched-chain arrangement
Online Access:https://www.frontiersin.org/articles/10.3389/fnume.2025.1585027/full
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