A network pharmacology approach confirms Biejiaxiaozheng pills combat hepatic fibrosis by modulating macrophage inflammation and hepatic stellate cell activation

A network pharmacology approach confirms Biejiaxiaozheng pills combat hepatic fibrosis by modulating macrophage inflammation and hepatic stellate cell activation

Abstract Biejiaxiaozheng (BJXZ) pills, a traditional Chinese medicine, have demonstrated anti-fibrotic effects; however, their mechanisms in treating liver fibrosis remain unclear. This study aimed to explore the active targets and underlying mechanisms of BJXZ pills using network pharmacology and e...

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Bibliographic Details
Main Authors: Weibin Wu, Yanli Liao, Jiefei Liang, Mi Huang, Guifeng Zhang, Yuying Hu, Chao Yuan, Duanzhou Li
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Biejiaxiaozheng pills
Network pharmacology
Macrophage
Inflammation
HSCs
Fibrosis
Online Access:https://doi.org/10.1038/s41598-025-09002-1
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