Lipid metabolism disorder promoting retinal structural and functional damage in ApoE −/− mice with age superposition

Lipid metabolism disorder promoting retinal structural and functional damage in ApoE −/− mice with age superposition

Abstract This study aimed to establish a model of abnormal lipid metabolism in Apolipoprotein E (ApoE) knockout mice by feeding them a high-fat diet (HFD) and to investigate the impact of this abnormal lipid metabolism on retinal blood perfusion, structure, and function, particularly the retinal gan...

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Main Authors: Rucui Yang, Shaolang Chen, Tsz Kin Ng, Jiajian Liang, Shaofen Huang, Minru Deng, Zhenggen Wu, Yaru Sun, Changzhen Fu, Chi Pui Pang, Qingping Liu, Mingzhi Zhang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Acta Neuropathologica Communications
Subjects:
ApoE −/− mice
High‑fat diet
Lipid metabolism disorder
Blood perfusion
Retina
RGC damage
Online Access:https://doi.org/10.1186/s40478-025-02043-7
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https://doi.org/10.1186/s40478-025-02043-7

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