Activating STAT3 mutations in CD8+ T-cells correlate to serological positivity in rheumatoid arthritis

Activating STAT3 mutations in CD8+ T-cells correlate to serological positivity in rheumatoid arthritis

ObjectivesLarge granular lymphocyte (LGL) leukemia is a rare hematologic malignancy characterized by clonal expansion of cytotoxic T-cells frequent somatic activating STAT3 mutations. Based on the disease overlap between LGL leukemia rheumatoid arthritis (RA)a putative role for CD8+ T-cells in RA we...

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Main Authors: Katharine B. Moosic, Thomas L. Olson, Mark Freijat, Samara Khalique, Cait E. Hamele, Bryna Shemo, Jesse Boodoo, William Baker, Gitanjali Khurana, Matthew Schmachtenberg, Tristin Duffy, Aakrosh Ratan, Erika Darrah, Felipe Andrade, Marieke Jones, Kristine C. Olson, David J. Feith, Donald L. Kimpel, Thomas P. Loughran
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
large granular lymphocytic leukemia
anti-citrullinated protein antibodies
CD8-positive T-lymphocytes
rheumatoid factor
stat3
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1466276/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1466276/full

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