Development of a candidate mRNA vaccine based on Multi-Peptide targeting VP4 of rotavirus A: an immunoinformatics and molecular dynamics approach

Development of a candidate mRNA vaccine based on Multi-Peptide targeting VP4 of rotavirus A: an immunoinformatics and molecular dynamics approach

Abstract Rotavirus (RV) is a common double-stranded RNA virus that causes diarrheal disease in young children. The prevalent species, Rotavirus A (RVA), is responsible for over 90% of human RV infections. With significant morbidity and mortality, this pathogen poses a serious global health challenge...

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Bibliographic Details
Main Authors: Cena Aram, Leila Karami, Mohammad Mehdi Ranjbar
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Rotavirus A
mRNA vaccine
Immunoinformatics
Multi-peptide
Molecular dynamics simulation
Computational immunology
Online Access:https://doi.org/10.1038/s41598-025-07433-4
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https://doi.org/10.1038/s41598-025-07433-4

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