TGF-β/JNK axis mediates mitochondrial damage and macrophage cGAS-STING activation in liver Mallory-Denk body pathogenesis
Abstract Background Mallory-Denk bodies (MDBs) are characteristic proteins and inflammatory aggregates appeared in drug-induced chronic liver injury and various chronic liver disease. MDBs formation is often accompanied with mitochondrial damage and inflammatory environment. However, how mitochondri...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-06-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-025-06618-9 |
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