TGF-β/JNK axis mediates mitochondrial damage and macrophage cGAS-STING activation in liver Mallory-Denk body pathogenesis

TGF-β/JNK axis mediates mitochondrial damage and macrophage cGAS-STING activation in liver Mallory-Denk body pathogenesis

Abstract Background Mallory-Denk bodies (MDBs) are characteristic proteins and inflammatory aggregates appeared in drug-induced chronic liver injury and various chronic liver disease. MDBs formation is often accompanied with mitochondrial damage and inflammatory environment. However, how mitochondri...

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Bibliographic Details
Main Authors: Yi Shi, Maoping Huang, Wanmei Zhou, Yi Zhao, Jiuying Zhao, Bei Zhong, Samuel W. French, Xiaoping Tang, Hui Liu
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Translational Medicine
Subjects:
Inflammation
Mallory-Denk bodies (MDBs)
Mitochondrial damage
cGAS-STING signaling
TGF-β/JNK axis
Online Access:https://doi.org/10.1186/s12967-025-06618-9
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https://doi.org/10.1186/s12967-025-06618-9

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