MSFragger-DDA+ enhances peptide identification sensitivity with full isolation window search

Abstract Liquid chromatography-mass spectrometry based proteomics, particularly in the bottom-up approach, relies on the digestion of proteins into peptides for subsequent separation and analysis. The most prevalent method for identifying peptides from data-dependent acquisition mass spectrometry da...

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Bibliographic Details
Main Authors: Fengchao Yu, Yamei Deng, Alexey I. Nesvizhskii
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58728-z
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