Effects of exercise training on the nigrostriatal glutamatergic pathway and receptor interactions in Parkinson’s disease: a systematic review

Effects of exercise training on the nigrostriatal glutamatergic pathway and receptor interactions in Parkinson’s disease: a systematic review

BackgroundThe excitatory imbalance of glutamatergic neurons, caused by insufficient input from dopaminergic neurons, contributes the pathogenesis of Parkinson’s disease (PD). Exercise training is one of the non-pharmacological, non-invasive therapeutic approaches.ObjectiveThis systematic review is t...

Full description

Saved in:

Bibliographic Details
Main Authors:	Shahid Ishaq, Iqbal Ali Shah, Shin-Da Lee, Bor-Tsang Wu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-02-01
Series:	Frontiers in Aging Neuroscience
Subjects:	glutamate glutamatergic system glutamate receptors nigrostriatum Parkinson’s disease Parkinson
Online Access:	https://www.frontiersin.org/articles/10.3389/fnagi.2025.1512278/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Corticostriatal glutamate‐mediated dynamic therapeutic efficacy of electroacupuncture in a parkinsonian rat model
by: Xinxin Jiang, et al.
Published: (2024-12-01)

The regulation of glutamatergic nervous system in sleep-wake states and general anesthesia
by: Wei Luo, et al.
Published: (2025-02-01)

INTERMOLECULAR INTERACTIONS IN NEURONAL FUNCTIONAL SYSTEMS
by: A. L. Proskura, et al.
Published: (2015-01-01)

Transcriptomic and behavioral studies reveal that glutamate receptors are involved in depressive-like behavior in adult olive flounder Paralichthys olivaceus
by: Liangfang Liu, et al.
Published: (2025-01-01)

Functional state of the nigrostriatal system of Krushinsky – Molodkina rats during audiogenic seizure expression
by: N. A. Dorofeeva, et al.
Published: (2016-05-01)

Palmitoylethanolamide supplementation for human health: A state-of-the-art systematic review of Randomized Controlled Trials in patient populations
by: R. Bortoletto, et al.
Published: (2025-02-01)

Investigating the influence of monosodium L-glutamate on brain responses via scalp-electroencephalogram (scalp-EEG)
by: Ben Wu, et al.
Published: (2022-09-01)

Modulation of brain glutamate dehydrogenase as a tool for controlling seizures
by: Rasgado Lourdes A. Vega, et al.
Published: (2015-12-01)

Instrumental balance assessment in Parkinson's disease and parkinsonism. A systematic review with critical appraisal of clinical applications and quality of reporting
by: Andrea Merlo, et al.
Published: (2025-01-01)

From small to tall: breed-varied household pet dogs can be trained to detect Parkinson’s Disease
by: Lisa Holt, et al.
Published: (2024-10-01)

Molecular Insights Into the Sensory Adaption of the Cave‐Dwelling Leech Sinospelaeobdella wulingensis to the Karst Cave Environment
by: Xi Wen, et al.
Published: (2025-01-01)

Protective Effects of Apis Dorsata Honey Supplementation on Kidney Histopathology in Mice with Monosodium Glutamate Exposure
by: Sherbrina Bai Seenivasa Rao, et al.
Published: (2023-12-01)

Glutamate enhances shrimp antibacterial ability by boosting its cellular immunity
by: Lei Ma, et al.
Published: (2025-06-01)

Glycolytic pathways: The hidden regulators in Parkinson's disease
by: Jing Shen, et al.
Published: (2025-02-01)

Electroconvulsive treatment of a patient with Parkinson’s disease and moderate depression
by: John Erik Berg
Published: (2011-02-01)

Co-expression of glutamatergic and autism-related genes in the hippocampus of male mice with disturbances of social behavior
by: I. L. Kovalenko, et al.
Published: (2020-04-01)

Distinct sex differences in ethanol consumption and operant self-administration in C57BL/6J mice with uniform regulation by glutamate AMPAR activity
by: Sara Faccidomo, et al.
Published: (2025-01-01)

Integration of Therapeutic Components in the Rehabilitation of Patients with Parkinson’s Disease
by: Sonia Viviané Jiménez Carpi, et al.
Published: (2020-06-01)

Use of Acupuncture in the Rehabilitation Treatment of Patients with Parkinson's Disease
by: Julio López Argüelles, et al.
Published: (2023-04-01)

Safety assessment of monosodium glutamate based on intestinal function and flora in mice
by: Jinzhao Xu, et al.
Published: (2022-01-01)

Investigating the Effect of Temperature and Time of the Process of Producing Graphene Quantum Dots by Carbonization on Structural, Microstructural, and Optical Properties
by: M. Nazari, et al.
Published: (2024-12-01)

Mapping hippocampal glutamate in healthy aging with in vivo glutamate-weighted CEST (GluCEST) imaging
by: Maggie K. Pecsok, et al.
Published: (2025-01-01)

Synaptic modulation of glutamate in striatum of the YAC128 mouse model of Huntington disease
by: Judy Cheng, et al.
Published: (2025-02-01)

Anti-GluK2 antibody-positive autoimmune encephalitis concurrent with multiple myeloma: a case report
by: Zhengping Cheng, et al.
Published: (2025-01-01)

Value of multi-parameter 123I-MIBG scintigraphy in the differential diagnosis of Parkinson’s disease
by: Teng Xue, et al.
Published: (2025-01-01)

Enfoques sobre anestesia y enfermedad de Parkinson
by: Evangelina Dávila Cabo de Villa
Published: (2021-04-01)

Effect of Green Tea Extract-Enriched Diets on Insulin and Leptin Levels, Oxidative Stress Parameters and Antioxidant Enzymes Activities in Obese Mice
by: Bártíková Hana, et al.
Published: (2017-09-01)

Correlation between plasma glutamate and adiponectin in patients with type 2 diabetes
by: Hirofumi Nagao, et al.
Published: (2024-01-01)

Successful treatment of stiff-person syndrome with plasmapheresis: case report and literature review
by: M. Nasvytis, et al.
Published: (2023-10-01)

Evaluation of compliance and accuracy in Parkinson’s disease motor symptom tracking: a comparative study of digital and traditional paper diaries using a smartphone application (MyParkinson’s)
by: Nazli Durmaz Celik, et al.
Published: (2025-01-01)

Mechanisms underlying CSD initiation implicated by genetic mouse models of migraine
by: Daniela Pietrobon, et al.
Published: (2025-01-01)

Icaritin alleviates motor impairment and osteoporosis in Parkinson’s disease mice via the ER-PI3K/Akt pathway
by: Xianmei Lin, et al.
Published: (2025-01-01)

The Multifactorial Memory Questionnaire and Quality of Life: A Longitudinal Study in Parkinson’s Disease
by: Emily J. Corti, et al.
Published: (2025-01-01)

Astaxanthin-loaded brain-permeable liposomes for Parkinson’s disease treatment via antioxidant and anti-inflammatory responses
by: Thai-Duong Nguyen, et al.
Published: (2025-02-01)

Progress of deep brain stimulation for Parkinson's disease
by: BAI Yu⁃tong, et al.
Published: (2025-01-01)

Gene networks and metabolomic screening analysis revealed specific pathways of amino acid and acylcarnitine profile alterations in blood plasma of patients with Parkinson’s disease and vascular parkinsonism
by: A. A. Makarova, et al.
Published: (2025-01-01)

Cannabis oil in treating Parkinson’s disease: improvement of motor and non-motor symptoms: a case report
by: C. T. M. I. Issa, et al.
Published: (2025-01-01)

Genetic screening of South African families with Parkinson’s disease
by: S Bardien, et al.
Published: (2024-02-01)

Monosodium glutamate (MSG) exposure induced oxidative stress and disrupted testicular hormonal regulation, exacerbating reproductive dysfunction in male WISTAR rats
by: Adesua Emmanuel Ogunmokunwa, et al.
Published: (2025-03-01)

Hot shape transformation: the role of PSar dehydration in stomatocyte morphogenesis
by: Remi Peters, et al.
Published: (2025-01-01)