Avidity and variable domain spacing strongly influence the therapeutic potency of bispecific antibodies against Crimean-Congo hemorrhagic fever virus

Avidity and variable domain spacing strongly influence the therapeutic potency of bispecific antibodies against Crimean-Congo hemorrhagic fever virus

ABSTRACT Crimean-Congo hemorrhagic fever virus (CCHFV) is an enveloped, negative-sense RNA virus that is spread by ticks across Europe, Africa, and Asia and causes a lethal disease in humans (~30%–40% case fatality). There are currently no approved vaccines or therapeutics. Antibody-based therapeuti...

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Main Authors: Albert Wang, Stephanie R. Monticelli, Ariel S. Wirchnianski, Dafna M. Abelson, Ana I. Kuehne, Russell R. Bakken, Marissa Middlecamp, Michael Weingart, Olivia Vergnolle, Zachary A. Bornholdt, Crystal L. Moyer, Jacob L. Berrigan, Brandyn R. West, J. Maximilian Fels, Larry Zeitlin, Andrew S. Herbert, Kartik Chandran, Chowdhury Raihan Bikash, Jonathan R. Lai
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:mBio
Subjects:
Crimean-Congo hemorrhagic fever virus
monoclonal antibody
bispecific antibody
immunotherapy
Online Access:https://journals.asm.org/doi/10.1128/mbio.03202-24
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https://journals.asm.org/doi/10.1128/mbio.03202-24

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