Mechanistic Insights into the Adenosine A1 Receptor’s Positive Allosteric Modulation for Non-Opioid Analgesics

Mechanistic Insights into the Adenosine A1 Receptor’s Positive Allosteric Modulation for Non-Opioid Analgesics

The adenosine A1 receptor (A<sub>1</sub>R) is a promising target for pain treatment. However, the development of therapeutic agonists is hampered by adverse effects, mainly including sedation, bradycardia, hypotension, or respiratory depression. Recently discovered molecules able to over...

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Bibliographic Details
Main Authors: Tal Weizmann, Abigail Pearce, Peter Griffin, Achille Schild, Maren Flaßhoff, Philipp Grossenbacher, Martin Lochner, Christopher A. Reynolds, Graham Ladds, Giuseppe Deganutti
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Cells
Subjects:
adenosine A1 receptor
BnOCPA
MIPS521
non-opioid analgesia
GPCRs
Online Access:https://www.mdpi.com/2073-4409/13/24/2121
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