Assessment of the participation of sulfhydryl proteins in the glutathione peroxidase mimicry of diphenyl diselenide in the presence of thiol alkylating agent

Assessment of the participation of sulfhydryl proteins in the glutathione peroxidase mimicry of diphenyl diselenide in the presence of thiol alkylating agent

Abstract Diphenyl diselenide (DPDS) is an organoselenium which has garnered profound interest due to its reported antioxidant viz-a-viz glutathione peroxidase (GPx) mimetic activity which is ultimately speculated to rely on oxidation of free thiols or protein thiols critical to the activities of som...

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Bibliographic Details
Main Authors: Ebenezer Morayo Ale, Ige Joseph Kade, Mgbede Joy Timothy, Richard-Harris Nsenreuti Boyi, Steve Osagie Asuelimen, Victoria Ifeoluwa Ayo, Ebenezer Kayode Toluwalase, Moses Adondua Abah, Emmanuela Onyebuchi Nnamani
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Organoseleniums
Diphenyl diselenide
Glutathione peroxidase
Antioxidant
Thiols
Na+/K+-ATPase
Online Access:https://doi.org/10.1038/s41598-024-77767-y
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https://doi.org/10.1038/s41598-024-77767-y

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