PAK4 phosphorylates and stabilizes MYC to promote acute myeloid leukemia

MYC dysregulation plays a crucial role in acute myeloid leukemia (AML), yet the mechanisms governing its stabilization remain incompletely understood. MYC protein turnover is tightly regulated by post-translational modifications (PTMs), especially phosphorylation-dependent ubiquitination. Our previo...

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Bibliographic Details
Main Authors: Ting Xie, Peipei Sun, Hao Huang, Qilong Li, Hudan Liu, Jue Jiang
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Cell Insight
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Online Access:http://www.sciencedirect.com/science/article/pii/S2772892725000483
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