An advancement in developmental and reproductive toxicity (DART) risk assessment: evaluation of a bioactivity and exposure-based NAM toolbox

An advancement in developmental and reproductive toxicity (DART) risk assessment: evaluation of a bioactivity and exposure-based NAM toolbox

Traditional chemical safety assessment involves identifying the lowest level of a chemical that impacts endpoints measured in standardized animal studies to establish human exposure limits. In vitro assays have shown promise in providing points of departure that can be protective of human health whe...

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Bibliographic Details
Main Authors: Iris Mueller, Ashraf Abdelkhaliq, Paul Carmichael, Matthew Dent, Marleen Feliksik, Luke Flatt, Jade Houghton, José M. Horcas Nieto, Amer Jamalpoor, Predrag Kukic, Sophie Malcomber, Beate Nicol, Gopal Pawar, Claire Peart, Katarzyna Przybylak, Magdalena Sawicka, Katy Wilson, Kathryn Wolton
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Toxicology
Subjects:
new approach methodologies
risk assessment
developmental and reproductive toxicity
bioactivity
exposure
in silico
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2025.1602065/full
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https://www.frontiersin.org/articles/10.3389/ftox.2025.1602065/full

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