Design of high-affinity binders to immune modulating receptors for cancer immunotherapy

Design of high-affinity binders to immune modulating receptors for cancer immunotherapy

Abstract Immune receptors have emerged as critical therapeutic targets for cancer immunotherapy. Designed protein binders can have high affinity, modularity, and stability and hence could be attractive components of protein therapeutics directed against these receptors, but traditional Rosetta based...

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Main Authors: Wei Yang, Derrick R. Hicks, Agnidipta Ghosh, Tristin A. Schwartze, Brian Conventry, Inna Goreshnik, Aza Allen, Samer F. Halabiya, Chan Johng Kim, Cynthia S. Hinck, David S. Lee, Asim K. Bera, Zhe Li, Yujia Wang, Thomas Schlichthaerle, Longxing Cao, Buwei Huang, Sarah Garrett, Stacey R. Gerben, Stephen Rettie, Piper Heine, Analisa Murray, Natasha Edman, Lauren Carter, Lance Stewart, Steven C. Almo, Andrew P. Hinck, David Baker
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57192-z
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https://doi.org/10.1038/s41467-025-57192-z

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