The novel compound PICCS improves cell viability during cold storage and reduces pulmonary ischemia-reperfusion injury in a rat model

The novel compound PICCS improves cell viability during cold storage and reduces pulmonary ischemia-reperfusion injury in a rat model

Abstract A simple method to achieve better organ preservation is the addition of compounds to the preservation solution, which effectively inhibits cold injury. We aimed to develop novel compounds for better lung graft preservation using TY52156 as a seed compound, which reportedly inhibits cold inj...

Full description

Saved in:
Bibliographic Details
Main Authors: Yuhei Yokoyama, Masayasu Toyomoto, Nobuo Tanaka, Satona Tanaka, Shigeto Nishikawa, Hidenao Kayawake, Yuki Morimura, Hiromi Oda, Momono Yamauchi, Makoto Yamamoto, Toyofumi F. Chen-Yoshikawa, Masatoshi Hagiwara, Hiroshi Date
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Organ preservation
Ischemia-reperfusion injury
Cell death
PICCS
Online Access:https://doi.org/10.1038/s41598-025-99851-7
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41598-025-99851-7

Similar Items