Immunological analysis of LC16m8 vaccine: preclinical and early clinical insights into mpoxResearch in context

Immunological analysis of LC16m8 vaccine: preclinical and early clinical insights into mpoxResearch in context

Summary: Background: The global mpox outbreak (2022–2024) highlights the need for effective and safe vaccines, particularly for vulnerable populations. The LC16m8 vaccine, an attenuated vaccinia virus strain for smallpox, shows promise in inducing immunity against the monkeypox virus (MPXV). Method...

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Main Authors: Kouji Kobiyama, Daichi Utsumi, Yu Kaku, Eita Sasaki, Fumihiko Yasui, Tomotaka Okamura, Taishi Onodera, Asuka Joy Tobuse, Areej Sakkour, Ahmad Faisal Amiry, Tomoya Hayashi, Burcu Temizoz, Kaiwen Liu, Hideo Negishi, Noriko Toyama-Sorimachi, Michinori Kohara, Tatsuya Sawasaki, Junichi Takagi, Kei Sato, Yoshimasa Takahashi, Yasuhiro Yasutomi, Ken J. Ishii
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:EBioMedicine
Subjects:
Mpox
LC16m8 vaccine
Immunological evaluation
Antigen-specific immunity
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425001471
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