LncRNA gm40262 promotes liver fibrosis and parasite growth through the gm40262-miR-193b-5p-TLR4/Col1α1 axis

LncRNA gm40262 promotes liver fibrosis and parasite growth through the gm40262-miR-193b-5p-TLR4/Col1α1 axis

ABSTRACT Alveolar echinococcosis (AE) is a severe and life-threatening parasitic disease caused by Echinococcus multilocularis. Liver fibrosis is a significant pathological feature of advanced AE, characterized by the excessive production and accumulation of extracellular matrix (ECM). However, the...

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Bibliographic Details
Main Authors: Tingli Liu, Guiting Pu, Liqun Wang, Ziyu Ye, Hong Li, Rui Li, Yanping Li, Xiaola Guo, William C. Cho, Hong Yin, Yadong Zheng, Xuenong Luo
Format: Article
Language:English
Published: American Society for Microbiology 2025-04-01
Series:mBio
Subjects:
E. multilocularis
liver fibrosis
gm40262
miR-193b-5p
TLR4
Col1α1
Online Access:https://journals.asm.org/doi/10.1128/mbio.02287-24
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https://journals.asm.org/doi/10.1128/mbio.02287-24

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